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In the Phase 2 study the highest arm continued upward toward higher maintenance targets, but the core principle held throughout: escalate only after the current step is tolerated , in roughly four-week increments
As IKK- is the direct upstream kinase that phosphorylates IB-, leading to its degradation, we next examined whether decreased TNF-induced IB- phosphorylation by H 2 O 2 treatment was due to its effects on IKK- activity
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